The alt description for this image should be: "Dr. Brian Rogers, DO, Medical Director of Longevity Medicine, standing confidently in a blue shirt against a green background with the title 'Chronic Inflammatory Response Syndrome (CIRS): A Hidden Cause of Fatigue and Brain Fog' and bacterial/viral imagery, highlighting his expertise in treating this condition

Understanding When “Growing Pains” and Mood Changes Aren’t Normal in Children

April 06, 20262 min read



Growing up in the often humid, mold-prone environment of Minnesota—a place abundant with lakes—I now realize I was experiencing symptoms of CIRS (Chronic Inflammatory Response Syndrome). As a child under 15, I dealt with issues that were not only unusual, but clearly different from what my peers experienced. Looking back, these symptoms were likely tied to my environment and a condition that went unrecognized at the time.

Unusual Childhood Symptoms

One of the most persistent issues I faced was frequent nosebleeds. Despite how often they occurred, they were usually dismissed as allergies or common reactions to humidity. In reality, frequent nosebleeds are not typical for a healthy child and may signal an underlying issue.

I also experienced severe muscle cramps that were often labeled as “growing pains.” These were not mild or occasional—they were intense enough to bring me to tears and required my mother’s help in the middle of the night. Pain of that severity in a young child should not be easily dismissed and may point to deeper inflammatory responses associated with CIRS.

Mood Changes and Behavioral Signs

CIRS doesn’t only affect the body; it can also impact mood and behavior. Children with CIRS may show irritability, mood swings, anxiety, or even depression that go beyond what’s typically expected. These symptoms can sometimes be misinterpreted as developmental or psychological conditions, including autism spectrum disorders or syndromes like PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome).

Cognitive Impacts

Unlike adults, children with CIRS may not always present with obvious fatigue. Instead, they may experience brain fog or difficulty concentrating. This can show up as a sudden drop in academic performance or trouble keeping up in school, even in otherwise capable and intelligent children.

Recognizing and Addressing CIRS

Recognizing these patterns is key to early intervention. Unexplained physical symptoms, combined with noticeable shifts in mood or cognitive function, should not be overlooked. Greater awareness among parents, educators, and healthcare providers can help ensure that children receive the support and care they need.

Understanding that these symptoms are not simply part of “growing up” is important. By identifying and acknowledging CIRS in children, we can move toward better outcomes and a higher quality of life for those affected.

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